Bowel cancer - GIST

Introduction

Introduction

GISTs are caused by a mutation of the interstitial cells of Cajal (ICC) found in the smooth muscle of the gastrointestinal tract

ITAcC’s medical team maintains direct contact with all the specialists involved for deciding what the best treatment is for GIST patients

At iTAcC we have a highly specialized medical team in the diagnosis and treatment of gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GIST) are rare neoplasms of the digestive system that originate in the wall of the esophagus, stomach or intestine. These tumors come from a mutation in the interstitial cells of Cajal (ICC) found in the smooth muscle of gastrointestinal tract.  They are responsible for movement of contraction and peristaltic waves of the entire gastrointestinal tract. Such a mutation causes uncontrolled growth leading to the formation of a tumor. Around 5% of cases are not related to any specific DNA alteration, especially those occurring in children and associated with syndromes such as neurofibromatosis type I.

The disease commonly appears between the ages of 55 and 65, although there are exceptional cases that occur before 40.  It mainly affects males and may appear in children on sporadic occasions.

The medical team at iTAcC is highly specialized in the diagnosis and treatment of gastrointestinal stromal tumors. All treatment decisions are multidisciplinary, involving specialists in the digestive system (endoscopists), general surgeons, radiologists, pathologists, radiation oncologists, and medical oncologists. Nutritionists and physiotherapists at iTAcC provide rehabilitative support to the patient during and after treatment. All of the aforementioned provides the best guarantee in the prevention, diagnosis and treatment of disease.